The disturbances of calcium-phosphorus metabolism and secondary hyperparathyroidism belong to frequent complications which develop in patients with chronic kidney disease on program hemodialysis. The indexes of calcium-phosphorus metabolism were studied in 96 patients with chronic kidney disease receiving hemodialysis treatment program. The data were compared with the results of similar foreign researches. It was found that the calcium, phosphorus and PTH blood levels do not correspond to the target levels according to NKF-K/DOQI 2003 in most hemodialysis patients. The secondary hyperparathyroidism is found more frequently in examined patients than in similar patients in Western and Central Europe, Turkey, USA and Japan. The cases of severe and extremely severe secondary hyperparathyroidism prevailed among the patients. Secondary hyperparathyroidism is most frequently accompanied by hypercalcemia and hyperphosphatemia. Found disturbances require the regular control of calcium-phosphorus metabolism indexes and more wide usage of noncalcium-containing phosphate-binders and active metabolite of vitamin D in this population of patients.

Vascular-thrombocytic and plasmic haemostasis research data in predialysis patients with carotid artery calcification have been presented in the article. It has been established that a carotid plaque calcification under the predialysis stage of chronic kidney disease is combined with the activation of thrombocytes, hypercoagulation, and a simultaneous depression of blood fibrinolytic activity, indicating a prothrombotic character of disorders of haemostasis system, as well as the severity of chronic DIC-syndrome. It has been shown the role of close relationship of haemostasis parameters and nitric oxide in mechanisms of calcification of carotid vessels in predialysis patients.

The aim of our work was to study the regulation of acid-base status and blood acid - renal excretory function in patients with COPD, II and III stages. Analysis of data obtained from the survey of 82 people, suggests that even during the most severe stages of COPD, there is activation of acid - renal excretory function and the inclusion of renal mechanisms in the regulation of CBS.

Work of department of HD of GI «Institute of nephrology of AMSU» is analysed and compared to mean for Ukraine and some regions according National register of patients with chronic kidney diseases 2009.

Considering the literary data about a role of disorders of kidney function in increase in death rate patients with congestive heart failure (CHF), frequencies of hospitalization and reduction of efficiency of therapy, improvement of existing recommendations depending from glomerular filtration rate (GFR) is necessary. The aim of the study was to assess protein spectrum of urine, endothelial function, proteolysis of fibronectine in patients with CHF and renal insufficiency, development the cardiorenal syndrome. Observed 56 patients in age 45-69 years with CHF I-III NYHA functional class with ejection fraction >45%, due to coronary artery disease and arterial hypertension. The patient was divided in two groups depending from GFR: the 1st – 21 patients with GFR=90 ml/min/1,73m2, the 2nd – 35 patients with GFR90=60 ml/min/1,73m2. The chosen groups of patients essentially didn’t differ on a functional condition of a myocardium, morphology of heart, endothelial function. More significant changes from the nephritic filter at patients with GFR90=60 ml/min/1,73m2, and also deeper degree of fibronectin proteolysis allow to assume an independent role of a kidney that demands the further studying on larger population of patients.